Final answer:
The correct order for the protein binding of local anesthetics from highest to lowest is bupivacaine > lignocaine > prilocaine > procaine.
Step-by-step explanation:
The question asks for the protein binding of local anesthetics in decreasing order. Local anesthetics like procaine, lidocaine, and bupivacaine function by blocking sodium channels, thus preventing sodium ions from moving across neuronal membranes which is key to their anesthetic effect. Compounds like procaine, also known as Novocain, have structures with hydrophilic and hydrophobic domains, as well as intermediate alkyl chains, and may contain ester or amide linkages. The correct order of protein binding strength from highest to lowest is bupivacaine > lignocaine > prilocaine > procaine.