Final answer:
The incorrect statement is C. Decrease renal impairment, as both NSAIDs and COX-2 inhibitors can lead to renal impairment, especially in individuals with pre-existing kidney conditions.
Step-by-step explanation:
Nonsteroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors both work to reduce the production of prostaglandins which play a key role in inflammation and pain. NSAIDs, such as aspirin, ibuprofen, and naproxen, inhibit the cyclooxygenase enzymes (COX-1 and COX-2) necessary for prostaglandin synthesis, leading to reduced inflammation and pain. However, they can also cause side effects like gastrointestinal ulcers, increased risk of heart attack, and kidney disease. On the other hand, COX-2 inhibitors like celecoxib (Celebrex) are designed to selectively block the COX-2 enzyme, thought to provide anti-inflammatory effects with a potentially lower risk of gastrointestinal issues.
The incorrect statement among the options provided is C. Decrease renal impairment. Both NSAIDs and COX-2 inhibitors can affect kidney function, and their use may lead to renal impairment rather than decrease it. On the contrary, they can exacerbate renal issues, especially in patients with pre-existing kidney disease.
While COX-2 inhibitors may decrease gastrointestinal symptoms (A) when compared to traditional NSAIDs, they can still precipitate asthma attacks (B) in susceptible individuals and do not typically cause coagulopathy (D) due to their specific inhibition of the COX-2 enzyme.