Final answer:
Cultural modifications do not exclude skeletal remains from forensic significance; instead, they can provide valuable insights into historical events and practices, as evidenced by the excavation of the Jamestown colony.
Step-by-step explanation:
The question whether cultural modifications would most likely exclude the skeletal individual from the category of forensic significance is false. Forensic anthropologists not only determine the identity of the deceased but also study any modifications to the skeleton that might give insight into historical or cultural practices.
As was the case with the Jamestown colony excavation cut marks on a skull led to the conclusion of cannibalism during a time of severe starvation. This indicates that cultural modifications can indeed be of high forensic value in providing context and understanding to past events.