Final answer:
Actinic Keratosis has irregular borders, which is indicative of many skin conditions that could precede skin cancer. The ABCDE mnemonic, particularly the 'Borders' aspect, is a key factor in diagnosing melanoma.
Step-by-step explanation:
Actinic Keratosis has irregular borders. Actinic Keratosis is a skin condition often seen as a precursor to skin cancers like squamous cell carcinoma, and it can manifest as splotches on the skin with a non-uniform appearance. In contrast, when discussing melanoma, a type of skin cancer, it's notable for presenting large brown or black patches that feature uneven borders and possibly a raised surface.
Early detection of skin cancers is aided by remembering the ABCDEs of melanoma: Asymmetry, Borders, Color, Diameter, Evolving; where borders are specifically highlighted as irregular in shape, aiding in the diagnosis and differentiation of these conditions from benign moles.