Final answer:
The clinical manifestation not commonly seen with anaphylaxis is hypertension. Anaphylaxis typically involves a drop in blood pressure, upper airway edema, GI discomfort, and potential dizziness with syncope.
Step-by-step explanation:
The clinical manifestation that would not commonly be seen with anaphylaxis is c. hypertension. Anaphylaxis is a severe, potentially life-threatening allergic reaction that can occur rapidly. It most commonly presents with a dangerous drop in blood pressure (hypotension), not an increase. The other options, such as gastrointestinal (GI) discomfort, upper airway edema, and dizziness with syncope, are typical symptoms associated with anaphylactic reactions.
During anaphylaxis, a massive release of histamines and other chemicals from mast cells occurs, leading to vasodilation and increased permeability of blood vessels, which often results in a drop in blood pressure. Furthermore, epinephrine, which is the first-line treatment for anaphylaxis, works to constrict blood vessels and raise blood pressure, which would not be necessary if hypertension was a symptom. Symptoms such as respiratory distress, upper airway edema, and systemic reactions like GI discomfort and syncope due to decreased perfusion of the brain further characterize anaphylaxis.