Question

Mdm2 is a ubiquitin ligase that promotes polyubiquinates unphosphorylated p53. p53 is targeted to the proteosome where it is degraded. When p53 is phosphorylated, Mdm2 dissociates from p53

Answer 1

Mdm2 is a ubiquitin ligase that promotes the polyubiquitination of unphosphorylated p53, leading to its degradation in the proteasome. This process is regulated by the phosphorylation state of p53 and the dissociation of Mdm2 from it.

Step-by-step explanation:

Mdm2 is a ubiquitin ligase that promotes the polyubiquitination of unphosphorylated p53. When p53 is unphosphorylated, it is targeted to the proteasome where it is degraded. However, when p53 is phosphorylated, Mdm2 dissociates from p53, preventing its degradation.