Final answer:
When prednisone is prescribed for a client with diabetes mellitus who is taking humulin neutral protamine hagedorn insulin daily, the nurse can anticipate a change in the insulin prescription to manage the increased blood glucose levels caused by prednisone.
Step-by-step explanation:
When prednisone is prescribed for a client with diabetes mellitus who is taking humulin neutral protamine hagedorn insulin daily, the nurse can anticipate a change in the insulin prescription. Prednisone is a glucocorticoid medication that can increase blood glucose levels by impairing insulin's ability to lower blood sugar. Since the client is already taking insulin, the nurse may need to increase the insulin dose or switch to a different type of insulin to effectively manage the increased blood glucose levels caused by prednisone.