Final answer:
Non-Bacterial Thrombotic Endocarditis (NBTE) is caused by underlying hypercoagulable states, such as acquired or inherited conditions. Chronic inflammation, malignancies, and tissue damage can also lead to NBTE.
Step-by-step explanation:
Non-Bacterial Thrombotic Endocarditis (NBTE) is a condition characterized by the formation of vegetations on the heart valves without the presence of bacteria. The most common cause of NBTE is underlying hypercoagulable states, which increase the risk of clot formation. These hypercoagulable states can be acquired, such as in cancer or autoimmune diseases, or they can be inherited, such as in Factor V Leiden mutation or Protein C or S deficiency. Other conditions that can cause NBTE include chronic inflammation, malignancies, and tissue damage.