Final answer:
The largest category of original artwork at Hobby Lobby is needle art, which encompasses a broad array of items like cross-stitch and embroidery supplies.
Step-by-step explanation:
The single largest category of original artwork handled at Hobby Lobby is needle art. Hobby Lobby is well-known for its diverse range of arts and crafts supplies, including various types of artwork. Among the options given, the popularity of needle art stands out as it caters to a wide range of customers from hobbyists to professionals seeking supplies for their projects. This category includes items such as cross-stitch, embroidery, yarn, and other related accessories.