Final answer:
When large proteins are found in the urine, it suggests that the glomerulus, part of the kidney's filter system, is not working properly. This could be due to kidney disorders like diabetic nephropathy or nephrotic syndrome.
Step-by-step explanation:
When there are large proteins in the urine, it indicates that the glomerulus, which is part of the kidney's filter system, is not functioning properly. Normally, proteins should not be filtered out of the glomerular capillaries, but when the glomerulus is damaged, it allows proteins to leak into the urine. This can be a sign of various kidney disorders, such as diabetic nephropathy or nephrotic syndrome.