Final answer:
In a cardiac arrest, the first drug to administer is epinephrine as it helps increase blood flow to the heart and brain.
Step-by-step explanation:
In a cardiac arrest situation where ventricular fibrillation has been refractory to a second shock, the first drug to administer is epinephrine.
Epinephrine is a medication that acts as a potent vasoconstrictor, meaning it constricts blood vessels in the body. In the case of cardiac arrest, it helps increase blood flow to the heart and brain, improving chances of survival.
In addition to epinephrine, other medications may be used in the management of ventricular fibrillation, including antiarrhythmics such as amiodarone or lidocaine.