Final answer:
The 'BH123' in the question seems to be a typo, and is likely referring to Bcl2 family proteins such as Bak and Bax. These proteins aid in the release of cytochrome C from the mitochondria, triggering the caspase cascade which ultimately leads to apoptosis in the intrinsic pathway.
Step-by-step explanation:
Role of BH123 in Apoptosis
The term 'BH123' appears to be a typographical error or an incorrect reference in the context of cell apoptosis. Based on the information provided, it seems the query intends to address the role of proteins related to the Bcl2 gene such as Bak and Bax in the intrinsic pathway of apoptosis. These proteins are crucial components of the outer mitochondrial membrane channels. When these proapoptotic proteins are activated, they allow the release of cytochrome C into the cytoplasm, initiating a cascade of molecular events that lead to apoptosis. This involves the activation of active caspases such as caspase 9, which in turn activate other caspases, resulting in a proteolytic cascade that leads to cell death.