Question

Which events does take place during the death receptor pathway of the tumor necrosis factor receptor (TNFR1) signaling?

Answer 1

The death receptor pathway of TNFR1 signaling involves the activation of specific intracellular proteins that lead to programmed cell death or apoptosis.

Step-by-step explanation:

The death receptor pathway of the tumor necrosis factor receptor (TNFR1) signaling involves specific events that ultimately lead to programmed cell death or apoptosis. When TNFR1 is activated by its ligand, TNF, it recruits several intracellular proteins, including FADD and caspase-8. This forms the death-inducing signaling complex, which activates caspase-8. Caspase-8 then triggers a cascade of proteolytic events leading to cell death.