Final answer:
Most neurons of the ENS are indeed not connected to the CNS, and they function autonomously to control various aspects of the gastrointestinal system. The ENS communicates with the CNS but does not depend on it to operate.
Step-by-step explanation:
The statement that most neurons of the Enteric Nervous System (ENS) are not connected to the Central Nervous System (CNS) is True. The ENS is capable of autonomous functions and consists of a large network of neurons embedded in the lining of the gut, controlling many aspects of the gastrointestinal system independently of the CNS.
Nonetheless, the ENS does communicate with the CNS via the autonomic nervous system, but it does not rely on the CNS to function.