Final answer:
Café-au-lait spots, dysfunctional endocrine system, and polyostotic fibrous dysplasia are characteristic of Mccune-Albright syndrome, a disorder caused by mutations in the GNAS gene that impact the endocrine system and bone development.
Step-by-step explanation:
The combination of café-au-lait spots, dysfunctional endocrine, and polyostotic fibrous dysplasia are all features of Mccune-Albright syndrome. This rare genetic disorder is characterized by the presence of pigment patches on the skin, fibrous dysplasia of bones, and a variety of endocrine problems, including precocious puberty and hyperthyroidism.
The syndrome is caused by mutations in the GNAS gene, leading to the activation of the adenylate cyclase pathway, and it does not follow a simple pattern of inheritance since the mutation occurs after fertilization, in the early stages of development (mosaicism).