Question

The benefit of selective COX-2 inhibitors in the treatment of imflammation is they:

A. have anti-inflammatory properties, but do not alter the gastric protection provided by COX-1
B. are antiemetic and antidiarrheal
C. cause platelet aggregation
D. do not cross placenta

Answer 1

Selective COX-2 inhibitors, such as Celebrex (celecoxib), offer anti-inflammatory effects while minimizing the risk of gastric complications. The correct answer is option A.

Step-by-step explanation:

The benefit of selective COX-2 inhibitors in the treatment of inflammation is that they have anti-inflammatory properties without altering the gastric protection provided by COX-1. This selective inhibition protects the stomach lining while still providing the desired anti-inflammatory effects.

Celecoxib, marketed as Celebrex, is an example of this category of drugs that has been designed to target the COX-2 enzyme more specifically, potentially reducing the risk of stomach problems that are typically associated with older non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen, and naproxen.

However, it is important to note that all NSAIDs, including COX-2 inhibitors, still carry the risk of causing stomach issues, along with other potential side effects such as heart attack and kidney disease.