Question

Pre-transfusion testing for a donor that received multiple blood products is important because:

a. Additional blood product will increase systolic pressure and damage the skin
b. Additional blood product can have a dilutional effect on donor blood effecting the detection of pre-existing antibodies and antigens
c. Additional blood product can cross match on patient blood making unnecessary influence on pre-transfusion sample
d. None of the above

Answer 1

Pre-transfusion testing is important for detecting dilutional effects on donor blood which can affect the detection of antigens and antibodies, and to ensure compatibility between donor and recipient to avoid hemagglutination and transfusion reactions.

Correct option is B

Step-by-step explanation:

Pre-transfusion testing for a donor who has received multiple blood products is important because additional blood product can have a dilutional effect on donor blood, affecting the detection of pre-existing antibodies and antigens. This is critical to ensure that any potential antibodies present in the recipient's blood do not react adversely with the antigens on the donor's blood, which could lead to hemagglutination and a possible transfusion reaction. The presence of such antibodies or the lack thereof is typically determined through pretransfusion protocols such as ABO and Rh typing, an antibody screening test, and a cross-match procedure to confirm compatibility between donor and recipient.

When a donor has received multiple transfusions, their blood may contain different antibodies and diluted antigen levels than expected, potentially complicating the detection and identification process for safe transfusion practices. A cross-match test with the recipient serum and donor red blood cells is essential to detect any agglutination that would indicate incompatibility.