Question

Why is a peripheral smear not sufficient to detect sickle cell disease? (Choose 2)

A) It cannot identify the presence of sickle hemoglobin.
B) It cannot provide information about the patient's white blood cell count.
C) It cannot assess bone marrow function.
D) It cannot determine the patient's platelet count.
E) It cannot detect the shape and characteristics of red blood cells under certain conditions.

Answer 1

A peripheral smear is not sufficient to detect sickle cell disease because it cannot confirm the presence of sickle hemoglobin and does not assess bone marrow function. Additional tests like hemoglobin electrophoresis are necessary for a definitive diagnosis.

Step-by-step explanation:

A peripheral smear is a test that can provide information about the shape and characteristics of red blood cells. While it is useful for detecting the sickle-shaped erythrocytes associated with sickle cell disease, it is not sufficient alone to diagnose the condition. This is because:

• A peripheral smear cannot identify the presence of sickle hemoglobin (HbS). Simply looking at the shape of the cells does not provide the biochemical confirmation that HbS is present.
• It cannot assess bone marrow function, which is important to evaluate in diseases like sickle cell anemia, as the bone marrow's response to anemia and other associated issues is a critical aspect of the disease.

A definitive diagnosis of sickle cell disease generally involves additional tests, such as hemoglobin electrophoresis, which can detect the specific abnormal hemoglobin responsible for sickle cell's characteristic symptoms.