Final answer:
The high incidence of two canals is the most probable reason for the high failure rate of root canal therapy on a mandibular incisor.
Step-by-step explanation:
The most probable reason for root canal therapy of a mandibular incisor having a relatively high failure rate is the high incidence of two canals (A). Mandibular incisors can often have more than one root canal, which can complicate the procedure and may lead to missed canals during treatment. Other anatomical challenges such as the narrow mesiodistal dimension of the root canal (E) and common distal curvature of the root (C) also make it difficult for endodontists to thoroughly clean and fill the tooth, potentially increasing the risk of failure. Furthermore, the presence of accessory canals (B) or pulpal calcific degeneration (D) may also contribute to root canal treatment challenges.