Final answer:
The biggest disagreement between Whites and Indians in history was the conflict over land and resources.
Step-by-step explanation:
The biggest disagreement between Whites and Indians in history was the conflict over land and resources. As White settlement expanded westward, Indigenous peoples were forced to move from their homelands, and White settlers frequently violated treaties that guaranteed Indigenous rights to live on their traditional lands. This led to clashes and violence between the two groups, often resulting in the displacement and loss of homeland for the Plains Indians. The recurring issues of land encroachment, treaty violations, and cultural clashes were the main sources of disagreement between Whites and Indians.