Question

The aggregation of Hb S occurs in the ___ state, thus the formation of aggregates is most likely to occur in the ___.

a) Oxygenated; lungs
b) Deoxygenated; tissues
c) Oxygenated; tissues
d) Deoxygenated; lungs

Answer 1

The aggregation of Hb S occurs in the deoxygenated state in tissues, where the oxygen concentration is lower. The correct option is B.

Step-by-step explanation:

The aggregation of hemoglobin S (HbS), which is associated with sickle-cell anemia, occurs in the deoxygenated state. This phenomenon is most likely to occur in the tissues, where the concentration of oxygen is lower.

There, the equilibrium shifts causing oxygen to be released from the hemoglobin, leading to the deoxygenation of HbS and promoting its aggregation into long, rigid fibers.

These fibers deform red blood cells into a sickle shape, impairing their ability to navigate through capillaries and deliver oxygen effectively.