Final answer:
Hydralazine, procainamide, and isoniazid have a high risk of causing drug-induced lupus erythematosus, a condition with symptoms similar to systemic lupus erythematosus.
Step-by-step explanation:
The drugs hydralazine, procainamide, and isoniazid have the highest risk of causing drug-induced lupus erythematosus (DILE). This is an autoimmune condition triggered by certain medications, and it shares many symptoms with systemic lupus erythematosus (SLE), although usually with a milder course. Specifically, hydralazine is an arterial vasodilator used to treat hypertension, and it has been well-documented to cause DILE. Procainamide, an antiarrhythmic medication, and isoniazid, an antimicrobial agent for tuberculosis, are also known to pose a high risk. It's important for patients on these medications to be monitored for symptoms such as muscle pain, joint pain, fatigue, and fever.