Question

The nurse is reviewing the medication orders for a patient who will be receiving linezolid (Zyvox) therapy. Which other medication or medication class, if ordered, would be a potential interaction concern?

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a. Calcium channel blockers
b. Phenytoin
c. Anticoagulants
d. Selective serotonin reuptake inhibitor antidepressants

Answer 1

Potential interactions of concern when a patient is receiving linezolid therapy include Selective Serotonin Reuptake Inhibitors (SSRIs), due to the increased risk of serotonin syndrome.

Step-by-step explanation:

The nurse concerned about a potential interaction with linezolid (Zyvox) therapy should be wary of any orders including Selective Serotonin Reuptake Inhibitor antidepressants (SSRIs). Linezolid acts as a weak monoamine oxidase inhibitor (MAOI), and concurrent use with drugs that affect the serotonergic system, such as SSRIs, can increase the risk of serotonin syndrome, which is a potentially life-threatening condition. Other medications highlighted, such as calcium channel blockers, phenytoin, or anticoagulants, do not have as significant an interaction risk with linezolid as the SSRIs do.