Final answer:
Isotretinoin cream is contraindicated for pregnant women or those who might become pregnant due to its teratogenic effects, which can lead to birth defects and cognitive problems. Contraindications also apply to individuals with hypersensitivity to isotretinoin or parabens and certain cases of acne.
Step-by-step explanation:
Isotretinoin cream is contraindicated for clients who are pregnant or who may become pregnant due to the high risk of teratogenic effects. Teratogenic substances are agents that can disturb the development of an embryo or fetus, leading to birth defects. Isotretinoin can cause serious birth defects, such as cardiac, oral, otological, thymic, and central nervous system abnormalities. Additionally, it is known to cause cognitive problems in one quarter of cases where the fetus is exposed.
Other contraindications include a history of hypersensitivity to isotretinoin or parabens (which are often used as preservatives in medication formulations) and certain forms of acne for which a milder treatment would be more appropriate. It is important to adhere to strict contraceptive measures when taking isotretinoin and to avoid use if there is any chance of pregnancy.