Final answer:
The combined population of the three major Alaskan cities is estimated to be around 354,636 people.
Step-by-step explanation:
According to the U.S. Census Bureau, the three major cities in Alaska are Anchorage, Fairbanks, and Juneau. As of 2010, Anchorage has a population of 291,826, Fairbanks has a population of 31,535, and Juneau has a population of 31,275. Therefore, the combined population of these three cities is around 354,636 people.