Question

3 classic CYP inducers

3 classic CTP inhibitors

A) Rifampin, Phenobarbital, St. John's Wort; Cimetidine, Ketoconazole, Grapefruit juice
B) Fluoxetine, Sertraline, Paroxetine; Ranitidine, Omeprazole, Famotidine
C) Atorvastatin, Simvastatin, Rosuvastatin; Carbamazepine, Phenytoin, Rifampin
D) Amoxicillin, Ciprofloxacin, Metronidazole; Acetaminophen, Ibuprofen, Aspirin

Answer 1

The correct option includes Rifampin, Phenobarbital, and St. John's Wort as CYP inducers, and Cimetidine, Ketoconazole, and Grapefruit juice as CYP inhibitors, crucial for drug therapy management.

Step-by-step explanation:

The correct option for 3 classic CYP inducers and 3 classic CYP inhibitors is A) Rifampin, Phenobarbital, St. John's Wort; Cimetidine, Ketoconazole, Grapefruit juice. Rifampin, Phenobarbital, and St. John's Wort are well-known CYP inducers which increase the metabolism of drugs leading to decreased drug concentrations. On the other hand, Cimetidine, Ketoconazole, and Grapefruit juice are classic CYP inhibitors which decrease the metabolism of drugs, potentially leading to higher concentrations and increased effects or side-effects of the drugs. These substances can significantly influence the pharmacokinetics of medications and are important considerations in the management of drug therapies.