Final answer:
Chronic ethanol use leads to neurochemical changes in the brain that can cause tolerance, withdrawal symptoms, and addiction, as well as impaired motor control, decision-making, and hippocampal dysfunction.
Step-by-step explanation:
The question asks about the effect of chronic ethanol use on brain receptors, specifically N₂B receptors, which seems to be a typographical error for NMDA receptors, as there are no N₂B receptors mentioned in current scientific literature. Chronic alcohol consumption can lead to changes in the function and regulation of neurotransmitter systems, such as the glutamatergic and GABAergic systems, which are involved in the brain's reward circuitry. These neurochemical changes can result in adaptations in the brain that contribute to the development of tolerance, withdrawal symptoms, and addiction. Problems like impaired motor control, decision-making, and hippocampal dysfunction can occur as well as excitotoxicity and cell death due to increased glutamatergic activity when alcohol consumption is ceased.