Question

Benzodiazepines act _____ on GABAa receptors. The maximum effect they elicit depends on the concentration of _____

a) Positively; GABA
b) Negatively; Glutamate
c) Directly; Serotonin
d) Inversely; Dopamine

Answer 1

Benzodiazepines have a positive effect on GABAA receptors and their maximum effect relies on the concentration of GABA.

Step-by-step explanation:

Benzodiazepines act positively on GABAA receptors. The maximum effect they elicit depends on the concentration of GABA. Therefore, the correct answer is a) Positively; GABA. Benzodiazepines increase the activity of GABA receptors in the brain, which has an inhibitory effect on neurons, leading to a quieting effect on the brain. These drugs are known as GABA agonists and are used for their calming effects to treat conditions like anxiety and insomnia. GABA, being the main inhibitory neurotransmitter in the CNS, when activated by benzodiazepines, allows more chloride ions to enter the neuron, hyperpolarizing it and making it less likely to fire.