Final answer:
Tolerance can develop between natural and synthetic opiates due to the body's adjustment to the presence of these drugs, necessitating higher doses for the same effect. However, this tolerance does not extend to CNS depressants, which work differently in the body.
Step-by-step explanation:
Tolerance can develop between natural and synthetic opiates, but not between opiates and CNS depressants. Tolerance is when the body adjusts to the presence of a drug, and greater amounts are needed to achieve the same effect. Opiates, or opioids, include drugs like heroin, morphine, and oxycodone, which are derived from the opium poppy or are synthetic versions that mimic the effects of the natural substances. Opioids bind with receptors in the brain and can produce pain relief and euphoria, but they also come with a high potential for abuse and addiction. Treatment for drug dependence may involve medications like methadone, which help alleviate withdrawal symptoms during rehabilitation.