Question

Sezary syndrome is characterized by atypical Cd₄⁺ cells with cerebriform nuclei seen on blood smear. Sezary syndrome is a progression of mycosis fungoides. What is the characteristic feature of Sezary syndrome?

1) Atypical Cd₄⁺ cells with cerebriform nuclei
2) Scary zombie brains
3) Mycosis fungoides
4) Blood smear

Answer 1

Sezary syndrome is characterized by the presence of atypical Cd4+ cells with cerebriform nuclei on a blood smear, marking its progression from mycosis fungoides.

Step-by-step explanation:

The characteristic feature of Sezary syndrome is the presence of atypical Cd4+ cells with cerebriform nuclei seen on a blood smear. This condition is, in fact, a progression of another disease known as mycosis fungoides. Sezary syndrome involves the proliferation of malignant T cells, which manifest in the skin and in the blood, leading to various clinical symptoms including erythroderma, lymphadenopathy, and pruritus.