Final answer:
The most common cause of adrenocortical insufficiency is an autoimmune response that leads to decreased production of cortisol and aldosterone. Diagnosis involves blood tests and treatment includes cortisol replacement therapy. Other causes include infections or pituitary problems.
Step-by-step explanation:
The most common cause of adrenocortical insufficiency, or Addison's disease, is an autoimmune response that damages the adrenal glands. This response leads to a decrease in the production of cortisol and sometimes aldosterone, which are critical hormones in regulating various body functions. In autoimmune Addison's disease (AAD), up to 80% of cases result from the body mistakenly attacking its adrenal tissue, leading to symptoms such as low blood pressure, fatigue, and salt cravings.
Diagnosing Addison's disease generally involves blood tests and possibly imaging tests. Treatments typically include lifelong cortisol replacement therapy. Other causes may include infections like tuberculosis, or a decrease in ACTH production due to a pituitary disorder. It's crucial for health care providers to evaluate for these causes when assessing a patient for suspected adrenocortical insufficiency.