Final answer:
Fresh water shortages create major global issues such as economic decline, regional conflicts, and impacts on food production.
Step-by-step explanation:
The major global issues created by fresh water shortages throughout the world include a decline in local economies, regional conflicts over water rights, and impacts on food production and availability. When there is a shortage of fresh water, crops and livestock may die, leading to a decrease in food supply. In addition, industries may have to stop their operations, resulting in job losses. Moreover, water scarcity can lead to conflicts between people and nations who compete for limited water resources.