Final answer:
Option (A), The cytokine that stimulates the differentiation of Th1 cells from naive CD4+ T cell pools is Interleukin-12 (IL-12), vital for the TH1-mediated immune response.
Step-by-step explanation:
The cytokine produced by macrophages that promotes the differentiation of Th1 cells from naive CD4+ T cell pools is Interleukin-12 (IL-12). IL-12 plays a crucial role in the differentiation process by influencing naive T cells to develop into Th1 cells, which then secrete their own cytokines to orchestrate immune responses against intracellular pathogens such as Mycobacterium tuberculosis.
IL-12 is essential in the TH1-mediated response, which gears the immune system toward battling intracellular invaders and, as part of this response, helps macrophages enhance their pathogen digestion capabilities.