Question

Among the given options, which type of cells primarily use perforin and granzyme to perform cell-mediated cytotoxicity?

a) Cytotoxic T cells
b) Natural killer cells
c) Cytotoxic T cells and natural killer cells
d) Helper T cells

Answer 1

Cytotoxic T cells primarily use perforin and granzyme to perform cell-mediated cytotoxicity.

Step-by-step explanation:

Perforin and granzyme are primarily used by cytotoxic T cells to perform cell-mediated cytotoxicity. Once activated, cytotoxic T cells recognize and kill infected cells through antigen presentation of pathogen-specific epitopes associated with MHC I. Perforin creates pores in the target cell, while granzymes enter the pores and induce apoptosis, resulting in the controlled and efficient destruction of infected cells.