Final answer:
The issue being referred to is slavery. The Founders' compromise on slavery had long-lasting consequences for future generations and the balance of power in the United States.
Step-by-step explanation:
The issue being referred to in the question is slavery. The compromise made by the Founders on slavery left a terrible burden for future generations. The Three-Fifths Compromise, contained in the second US Constitution, counted each black individual as three-fifths of a person for purposes of representation, which preserved the power of the majority and oppressed those designated as a minority. This compromise played a significant role in the national breakdown over slavery and the ongoing debate over the balance of power between the central government and state and local governments.