Question

62-year-old female patient presents with increasingly severe pain of the fingers, cold insensitivity of the hands (Raynaud's syndrome), 3-year history of GERD, tightening of the skin of the fingers with erythema, scaling, and telangiectasias, dry crepitant crackles in both lung bases, and hand X-ray shows loss of tufts of some DIP's and scattered soft tissue calcifications. What is the antibody associated with this presentation?

A) Anti-Smith (Anti-Sm)
B) Anti-Ro (SSA)
C) Anti-La (SSB)
D) Anti-centromere

Answer 1

The antibody associated with this presentation is Anti-centromere. It is commonly associated with CREST syndrome. Hence the correct answer is option D

Step-by-step explanation:

The antibody associated with this presentation is Anti-centromere.

This antibody is commonly associated with a condition known as CREST syndrome, which stands for calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia.

Based on the symptoms described, such as Raynaud's syndrome, tightening of the skin of the fingers with erythema, scaling, and telangiectasias, and the loss of tufts of some DIP's and scattered soft tissue calcifications on the hand X-ray, the patient is likely experiencing CREST syndrome.

Hence the correct answer is option D