Final answer:
Archibald Garrod made the connection between the role of defective protein in patients with alkaptonuria.
Step-by-step explanation:
Archibald Garrod made the connection between the role of defective protein in patients with alkaptonuria. Alkaptonuria is a recessive genetic disorder that results in the inability to properly metabolize phenylalanine and tyrosine amino acids, leading to various symptoms such as darkened skin and brown urine. The defective protein produced by these patients contributes to the disease's manifestation and complications.