Final answer:
Peptides messengers are broken down and removed from extracellular fluids through intracellular proteases, enzymatic deamination, and transition reactions or the Krebs cycle.
Step-by-step explanation:
Peptides messengers are usually broken down and removed from extracellular fluids by extracellular protease degradation and uptake of peptides in the cell. The peptides can then be broken down further into individual amino acids by additional intracellular proteases, and each amino acid can be enzymatically deaminated to remove the amino group. The remaining molecules can then enter the transition reaction or the Krebs cycle.