Question

An intracellular rise in cAMP can alter gene transcription through:

A. A rise in PKA binding to the cyclic AMP response element in DNA
B. A rise in PKA-induced phosphorylation of the CREB-binding protein (CBP)
C. A rise in active PKA and the subsequent phosphorylation of CREB
D. A rise in PKA induced binding of CREB-binding protein (CBP) to DNA

Answer 1

An intracellular rise in cAMP can alter gene transcription through a rise in PKA binding to the cyclic AMP response element in DNA.

Step-by-step explanation:

An intracellular rise in cAMP can alter gene transcription through A. A rise in PKA binding to the cyclic AMP response element in DNA. When cAMP levels increase, cAMP-dependent protein kinase (PKA) can bind to the cyclic AMP response element (CRE) in DNA, leading to changes in gene transcription.