Question

A phospholipid is cleaved by phospholipase C to produce second messengers DAG and IP3, both of which are realeased into the cytoplasm from the plasma membrane.

a. True
b. False

Answer 1

Phospholipase C cleaves a phospholipid to produce second messengers DAG and IP3, which are released into the cytoplasm from the plasma membrane. This statement is true.

Step-by-step explanation:

True.

The enzyme phospholipase C cleaves PIP₂ to form diacylglycerol (DAG) and inositol triphosphate (IP3), which are released into the cytoplasm from the plasma membrane. These products, DAG and IP3, serve as second messengers in signaling pathways. DAG remains in the plasma membrane and activates protein kinase C (PKC), while IP3 diffuses into the cytoplasm and binds to ligand-gated calcium channels in the endoplasmic reticulum to release Ca²+.