Question

In late pro-B cell, there is _____ rearrangement. This induces transcription from the ___ promoter since it brings it closer to enhancer sequences.

a) DJ; DJH
b) VJ; VJH
c) VDJ; VDJH
d) DJ; VDJH

Answer 1

In late pro-B cell, there is V(D)J rearrangement, which induces transcription from the VJH promoter.

Step-by-step explanation:

In late pro-B cell, there is V(D)J rearrangement. This induces transcription from the VJH promoter since it brings it closer to enhancer sequences. The V(D)J rearrangement refers to the process where Variable (V), Diversity (D), and Joining (J) gene segments rearrange to create diverse immunoglobulin antibody molecules. The rearrangement involves the excision and splicing of segments, resulting in a unique variable region in each antibody. The repositioning of the VJH promoter closer to enhancer sequences leads to increased transcription, allowing for the expression of the rearranged gene segments.