Question

When bisphosphonates are administered orally, how much of the medication reaches the bloodstream?

1) 10%
2) 25%
3) 50%
4) 75%

Answer 1

Approximately 1-10% of the oral dose of bisphosphonates is absorbed into the bloodstream. Factors such as the type of bisphosphonate and individual patient characteristics can influence the oral bioavailability. Following specific instructions provided by healthcare professionals is important for the administration of bisphosphonates.

Step-by-step explanation:

When bisphosphonates are administered orally, the amount of the medication that reaches the bloodstream varies depending on factors such as the type of bisphosphonate and individual patient characteristics. On average, approximately 1-10% of the oral dose of bisphosphonates is absorbed into the bloodstream.

For example, the oral bioavailability of alendronate, a commonly used bisphosphonate, is less than 1%. This means that less than 1% of the orally administered dose reaches the systemic circulation and exerts its therapeutic effects.

It's important to note that the oral bioavailability of bisphosphonates can be influenced by various factors such as the presence of food in the stomach, gastric pH, and interactions with other medications. Therefore, it is recommended to follow the specific instructions provided by healthcare professionals regarding the administration of bisphosphonates.