Question

In the gnomAD genome data downloaded in VCF format, where can you find information about the nearest gene and genomic location?

a. FORMAT column
b. INFO column
c. GENOTYPE column
d. FILTER column

Answer 1

In gnomAD VCF data, the nearest gene and genomic location details are found in the INFO column, which contains annotations like variant location and impact on genes.

Step-by-step explanation:

In the Genome Aggregation Database (gnomAD) genomic data provided in Variant Call Format (VCF), the information about the nearest gene and its genomic location can typically be found in the INFO column. The INFO column contains a variety of annotations for each variant which often includes the location of the variant, the predicted impact on nearby genes, and other annotations relevant to the variant's potential function or significance. These annotations can come from various bioinformatics tools that add useful information about genomic context around the VCF's raw variant data.