Question

What are the two basic ways to block neuromuscular transmission at the neuromuscular junction?

A) Presynaptically block receptor release; postsynaptically block ACh nicotinic receptors on the muscle end plate
B) Presynaptically block ACh release; postsynaptically block ACh muscarinic receptors on the muscle end plate
C) Presynaptically block ACh release; postsynaptically block ACh nicotinic receptors on the muscle end plate
D) All of the above
E) None of the above

Answer 1

The two basic methods to block neuromuscular transmission are to presynaptically block the release of acetylcholine and to postsynaptically block acetylcholine nicotinic receptors on the muscle end plate, as indicated in option C.

Step-by-step explanation:

The two basic ways to block neuromuscular transmission at the neuromuscular junction are:

A) Presynaptically by blocking the release of acetylcholine (ACh), and postsynaptically by blocking the ACh nicotinic receptors on the muscle end plate.

The correct answer to the question is option C: Presynaptically block ACh release; postsynaptically block ACh nicotinic receptors on the muscle end plate. Muscarinic receptors are not involved at the neuromuscular junction, which is a cholinergic synapse where ACh is released and binds primarily to nicotinic receptors to facilitate muscle contraction.