Final answer:
IgE antibodies are synthesized after initial exposure to an allergen and bind to mast cells, which can lead to the release of histamines and other mediators upon secondary exposure, causing allergic reactions and playing a role in defense against parasites.
Step-by-step explanation:
What Happens to IgE Antibodies
Immunoglobulin E (IgE) antibodies are crucial in the body’s immune response to parasites and in allergic reactions. Upon first exposure to an allergen, like pollen or pet dander, IgE is synthesized by plasma cells. These molecules have a high affinity for mast cells, which are found in tissues throughout the body.
When IgE binds to mast cells, it sensitizes them to the allergen. Upon secondary exposure, these sensitized mast cells quickly degranulate, releasing histamines and other inflammatory mediators. This immediate response can lead to various allergic symptoms, including hives, asthma, hay fever, and at its most extreme, anaphylaxis. Additionally, IgE plays a role in parasitic defenses, helping to eliminate parasites from the body.