Final answer:
The small intestine is the first organ to receive water-soluble nutrients after absorption from the gastrointestinal tract.
Step-by-step explanation:
After absorption into the bloodstream from the gastrointestinal tract, the small intestine is the first organ to receive water-soluble nutrients. The small intestine is a long tube-like organ with a highly folded surface containing finger-like projections called the villi. These structures increase the surface area of the intestine and increase absorption efficiency of the nutrients. Absorbed nutrients in the blood are carried into the hepatic portal vein, which leads to the liver.