Final answer:
Glucose will cross a plasma membrane using facilitated diffusion due to being large and polar, utilizing carrier proteins like the glucose transporter.
Step-by-step explanation:
Among the options given (lipids, glucose, and water), glucose is the substance that will only cross a plasma membrane using facilitated diffusion. Due to its relatively large size and polar nature, glucose cannot pass through the lipid bilayer by simple diffusion. Instead, glucose utilizes carrier proteins, such as the glucose transporter, to move down its concentration gradient through the cell membrane. In contrast, lipids, being nonpolar, can freely pass through the cell membrane, as can small polar molecules like water, although water often uses specialized channels called aquaporins for more efficient transport.