Question

A biopsy from a patient with a skeletal-muscle-wasting disease is analyzed biochemically and determined to have too little G-actin protein. All other proteins analyzed are at normal levels. The amino acid sequence of the G-actin protein shows no evidence of mutation in the amino acid sequence. Which of the following is a plausible hypothesis for why the cells have too little actin? The promoter for the G-actin gene may be mutated. O The spliceosome of the patient is defective and not removing introns from the mRNA of G-actin. The cells of the patient are deficient in UTP. O RNA polymerase Il is defective in the patient.

Answer 1

A plausible hypothesis for why the cells have too little actin is that the spliceosome of the patient is defective and not removing introns from the mRNA of G-actin. This would result in an abnormal or non-functional G-actin protein.

Step-by-step explanation:

A plausible hypothesis for why the cells have too little actin is that the spliceosome of the patient is defective and not removing introns from the mRNA of G-actin. This would result in an abnormal or non-functional G-actin protein. The spliceosome is responsible for removing introns, which are non-coding regions, from the pre-mRNA to produce mature mRNA that can be translated into a functional protein.