Question

Translocation between chromosomes 9 and 22 generate the ______ fusion protein that is responsible for chronic myelogenous leukemia

Answer 1

The translocation between chromosomes 9 and 22 produces the BCR-abl fusion protein, causing chronic myelogenous leukemia.

Step-by-step explanation:

The translocation between chromosomes 9 and 22 generates the BCR-abl fusion protein, which is responsible for chronic myelogenous leukemia (CML). This specific translocation is known as the Philadelphia chromosome, which is characterized by the abnormal fusion of the BCR and ABL1 genes. As a result, an oncogenic tyrosine kinase protein is produced that is implicated in the development of CML, promoting the uncontrolled proliferation of myeloid cells in the bone marrow.