Final answer:
Topoisomerases are enzymes that relieve the pressure resulting from supercoiling of DNA during replication by breaking and reforming DNA's nucleotide base pairs or phosphate backbone ahead of the replication fork.
Step-by-step explanation:
Topoisomerases are enzymes that are involved in relieving the pressure caused by supercoiling of DNA during replication. They do this by breaking and reforming DNA's nucleotide base pairs or phosphate backbone ahead of the replication fork. Topoisomerases play a crucial role in maintaining the integrity and stability of DNA during replication and transcription.